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STD Testing in Sioux Falls, South Dakota

7 STD and HIV testing locations in Sioux Falls, including 2 that list free testing.

Verify with the clinic before visiting. Hours, services, fees and appointment rules change. Call ahead to confirm. This directory is for information only and is not medical advice. In an emergency, call 911.

Heartland Health Resource Center

2500 W 49th St, Ste 103, Sioux Falls, SD 57105 · (605) 271-4813
Free testing listedHIVRapid HIV
Mon 8:30am – 4:30pm; Tue 8:30am – 4:30pm; Wed 8:30am – 4:30pm; Thu 8:30am – 4:30pm; Fri 8:30am – 4:30pm

South Dakota Department of Health – Sioux Falls HIV/AIDS and STD Testing Field Office

1501 S Highline Ave, Ste 1F, Sioux Falls, SD 57106 · (866) 315-9214
Free testing listedChlamydiaGonorrheaSyphilisHIVRapid HIVHepatitis CHepatitis B
Hours not listed

Avera – Infectious Disease and Public Health

6709 S Minnesota Ave, Ste 102, Sioux Falls, SD 57108 · (605) 322-7250
Sliding scaleChlamydiaGonorrheaSyphilisHIVHepatitis CHepatitis B
Hours not listed

Falls Community Health

521 N Main Ave, ste 101, Sioux Falls, SD 57104 · (605) 367-8793
Sliding scaleChlamydiaGonorrheaSyphilisHerpesHIVRapid HIVHepatitis CHepatitis B
Mon 7:30am – 5:00pm; Tue 7:30am – 5:00pm; Wed 9:00am – 5:00pm; Thu 7:30am – 5:00pm; Fri 7:30am – 5:00pm

Planned Parenthood North Central States – Sioux Falls Health Center

6511 W 41st St, Sioux Falls, SD 57106 · (605) 361-5100
Sliding scaleChlamydiaGonorrheaSyphilisHerpesHIVRapid HIV
Mon 9:00am – 5:00pm; Tue 9:00am – 5:00pm; Wed 11:00am – 7:00pm; Thu 9:00am – 5:00pm; Fri 9:00am – 5:00pm

Sanford Health – Sanford Infectious Disease and Travel Medicine Clinic

1420 W 22nd ST, Ste 401, Sioux Falls, SD 57105 · (605) 328-8120
ChlamydiaGonorrheaSyphilisHerpesHIVRapid HIVHepatitis CHepatitis B
Mon 8:00am – 5:00pm; Tue 8:00am – 5:00pm; Wed 8:00am – 5:00pm; Thu 8:00am – 5:00pm; Fri 8:00am – 12:00pm

South Dakota Urban Indian Health Incorporated – Urban Indian Health Program

1200 N West Ave, Sioux Falls, SD 57104 · (605) 339-0420
Sliding scaleChlamydiaGonorrheaSyphilisHerpesHIVRapid HIVHepatitis B
Mon 9:00am – 5:00pm; Tue 9:00am – 5:00pm; Wed 9:00am – 5:00pm; Thu 9:00am – 5:00pm; Fri 9:00am – 5:00pm

Frequently asked questions

Where can I get STD testing in Sioux Falls, SD?

This page lists 7 STD/HIV testing locations in Sioux Falls, SD from the CDC NPIN directory. Call ahead to confirm services and hours.

Is there free STD testing in Sioux Falls, SD?

2 of the 7 listed locations say they offer free STI and/or HIV testing. Eligibility can depend on age, income or residency. Many health departments and community health centers also use sliding-scale fees.

Do I need an appointment?

Appointment rules vary by location. Call before you go.

Can I get a rapid HIV test?

6 locations here list rapid HIV testing, which usually gives results during the same visit.

Which tests should I ask for?

Common tests include chlamydia, gonorrhea, syphilis, HIV and sometimes herpes or hepatitis. Which ones you need depends on your situation, so a clinician can help you decide. CDC recommends everyone ages 13 to 64 get tested for HIV at least once.

Is STD testing confidential?

Health care providers must keep your health information private. Some public health clinics offer anonymous HIV testing. Ask the clinic about their privacy policy.

Data: CDC NPIN. Page built 2026-11-03.